Is oxygen supply a limiting factor for survival during rewarming from profound hypothermia?

@article{Kondratiev2006IsOS,
  title={Is oxygen supply a limiting factor for survival during rewarming from profound hypothermia?},
  author={Timofei V. Kondratiev and Kristina Flemming and Eivind S. P. Myhre and Mikhail A. Sovershaev and Torkjel Tveita},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 1},
  pages={
          H441-50
        }
}
It has been postulated that unsuccessful resuscitation of victims of accidental hypothermia is caused by insufficient tissue oxygenation. The aim of this study was to test whether inadequate O2 supply and/or malfunctioning O2 extraction occur during rewarming from deep/profound hypothermia of different duration. Three groups of rats (n = 7 each) were used: group 1 served as normothermic control for 5 h; groups 2 and 3 were core cooled to 15 degrees C, kept at 15 degrees C for 1 and 5 h… Expand
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Effects of rewarming with extracorporeal membrane oxygenation to restore oxygen transport and organ blood flow after hypothermic cardiac arrest in a porcine model
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Investigation of the effects of extracorporeal membrane oxygenation (ECMO) rewarming to restore ḊO2 and organ blood flow after prolonged hypothermic cardiac arrest found that ECMO rewarming plays a crucial role in “the chain of survival” when resuscitating victims of hypothermia. Expand
Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32°C) With Spontaneous Circulation in an Intact Porcine Model
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The level to which CPR can replace CO and MAP during spontaneous circulation at normothermia was not affected by reduction in core temperature in the authors' setting and this fundamental new knowledge is important in that it encourages early and continuous CPR in accidental hypothermia victims during evacuation and transport. Expand
Myocardial mechanical dysfunction and calcium overload following rewarming from experimental hypothermia in vivo.
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Findings indicate that hypothermia-induced alterations in the Ca2+-handling result inCa2+ overload during hypotheria, which may contribute to myocardial failure during and after rewarming. Expand
Organ blood flow and O2 transport during hypothermia (27°C) and rewarming in a pig model
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In a porcine model of accidental hypothermia, despite a significantly reduced cardiac output during rewarming, normal blood flow and O2 supply in vital organs is found owing to patency of adequate physiological compensatory responses. Expand
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These in vitro experiments indicate that calcium homoeostasis and myofilament properties are affected by temperature in a very complex manner, and investigate whether an increase in cellular [Ca] may be responsible for the cardiac insufficiency. Expand
Comparison Between Two Pharmacologic Strategies to Alleviate Rewarming Shock: Vasodilation vs. Inodilation
TLDR
The vasodilator properties of LS and SNP are interpreted to be the primary source to increase organ blood flow, superior to the increase in CO, during rewarming from hypothermia. Expand
Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits.
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The present study shows impaired autonomic control of cardiovascular function after rewarming from severe hypothermia, which indicates that dysfunction of the autonomic nervous system is an important part of the pathophysiology. Expand
The effect of hypothermia and rewarming on cardiac electrophysiology and mechanical function
TLDR
The effect of hypothermia and rewarming on aspects of cardiac inotropy and excitability in rabbit hearts was examined, with a conclusion supported by the anti-arrhythmic effect of heptanol at 31°C. Expand
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