Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?

@article{MacNee2001IsOS,
  title={Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?},
  author={W. MacNee and Irfan Rahman},
  journal={Trends in molecular medicine},
  year={2001},
  volume={7 2},
  pages={55-62}
}
There is now considerable evidence for an increased oxidant burden in patients with chronic obstructive pulmonary disease (COPD). Oxidative stress is a critical feature in the pathogenesis of COPD, since it results in inactivation of antiproteinases, airspace epithelial injury, MUCUS HYPERSECRETION, increased influx of neutrophils into the lungs, transcription factor activation and gene expression of pro-inflammatory mediators. Antioxidants should therefore not only protect against the direct… CONTINUE READING

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