Is osteoarthritis a metabolic disease?

  title={Is osteoarthritis a metabolic disease?},
  author={J{\'e}r{\'e}mie Sellam and Francis Berenbaum},
  journal={Joint, bone, spine : revue du rhumatisme},
  volume={80 6},
Obesity, together with aging and injury, is among the main risk factors for osteoarthritis. Obesity-related osteoarthritis can affect not only the weight-bearing joints, but also the hands, suggesting a role for circulating mediators released by the adipose tissue and known as adipokines. Thus, osteoarthritis may have a systemic metabolic component. Evidence from both epidemiological and biological studies support the concept of metabolic osteoarthritis, defined as a broad clinical phenotype… CONTINUE READING
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