Is motor neuron disease-inclusion dementia a forme fruste of amyotrophic lateral sclerosis with dementia? An autopsy case further supporting the disease concept.

@article{Toyoshima2005IsMN,
  title={Is motor neuron disease-inclusion dementia a forme fruste of amyotrophic lateral sclerosis with dementia? An autopsy case further supporting the disease concept.},
  author={Yasuko Toyoshima and C. Tan and Tetsuro Kozakai and Masaharu Tanaka and Hitoshi Takahashi},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2005},
  volume={25 3},
  pages={214-9}
}
We report the autopsy findings of a 62-year-old man who exhibited progressive FTD 10 years before the appearance of muscle weakness and wasting, and who died approximately 11 years after onset of the symptoms. Degeneration and atrophy of the frontal and temporal lobes, which contained ubiquitin-positive neuronal inclusions and dystrophic neurites, were evident. Circumscribed degeneration affecting the hippocampal CA1-subiculum border zone was also a feature. Moreover, degeneration was present… CONTINUE READING

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