Is mitochondrial dysfunction a cause of insulin resistance?

@article{Turner2008IsMD,
  title={Is mitochondrial dysfunction a cause of insulin resistance?},
  author={Nigel Turner and Leonie K Heilbronn},
  journal={Trends in Endocrinology & Metabolism},
  year={2008},
  volume={19},
  pages={324-330}
}
Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise factors that lead to insulin resistance have not been elucidated fully, but there is a strong association between insulin resistance and inappropriate lipid accumulation in insulin-target tissues. Over the past decade, several studies have reported changes in markers of mitochondrial metabolism in insulin-resistant individuals. These observations have led to the theory that compromised mitochondrial… CONTINUE READING
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