Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

@article{Malik2013IsMD,
  title={Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?},
  author={Afshan N Malik and Anna Czajka},
  journal={Mitochondrion},
  year={2013},
  volume={13 5},
  pages={
          481-92
        }
}
Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear genome ratio (Mt/N) using real time quantitative PCR, have been reported in a broad range of human diseases, such as diabetes and its complications, obesity, cancer, HIV complications, and ageing. We propose the hypothesis that MtDNA content in body fluids and tissues could be a biomarker of mitochondrial dysfunction and… CONTINUE READING

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