Is methoxydine a new rapid acting antidepressant for the treatment of depression in alcoholics?

@article{Coppola2013IsMA,
  title={Is methoxydine a new rapid acting antidepressant for the treatment of depression in alcoholics?},
  author={M. Coppola and R. Mondola},
  journal={Medical hypotheses},
  year={2013},
  volume={81 1},
  pages={
          10-4
        }
}
  • M. Coppola, R. Mondola
  • Published 2013
  • Medicine
  • Medical hypotheses
  • Methoxydine is a dissociative anaesthetic belonging to the arylcyclohexylamine class. This substance shows pharmacodynamic similarities with ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine, results of binding assays have shown that methoxydine is an uncompetitive antagonist of NMDA receptor approximately as potent as ketamine, but less potent than PCP. Furthermore, unlike ketamine, it acts as a dopamine, serotonin, and noradrenaline reuptake inhibitor… CONTINUE READING
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