Is methoxydine a new rapid acting antidepressant for the treatment of depression in alcoholics?

  title={Is methoxydine a new rapid acting antidepressant for the treatment of depression in alcoholics?},
  author={M. Coppola and R. Mondola},
  journal={Medical hypotheses},
  volume={81 1},
  • M. Coppola, R. Mondola
  • Published 2013
  • Medicine
  • Medical hypotheses
  • Methoxydine is a dissociative anaesthetic belonging to the arylcyclohexylamine class. This substance shows pharmacodynamic similarities with ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine, results of binding assays have shown that methoxydine is an uncompetitive antagonist of NMDA receptor approximately as potent as ketamine, but less potent than PCP. Furthermore, unlike ketamine, it acts as a dopamine, serotonin, and noradrenaline reuptake inhibitor… CONTINUE READING
    3 Citations
    From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.
    • 146
    • PDF
    1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances.
    • 7
    Phencyclidine-Based New Psychoactive Substances.
    • 12


    Methoxetamine: from drug of abuse to rapid-acting antidepressant.
    • 37
    • PDF
    Opiates as antidepressants.
    • 102
    Medications acting on the GABA system in the treatment of alcoholic patients.
    • 39
    The use of selective serotonin reuptake inhibitors in treating alcoholic subtypes.
    • H. Pettinati
    • Psychology, Medicine
    • The Journal of clinical psychiatry
    • 2001
    • 64
    Family History of Alcohol Dependence and Initial Antidepressant Response to an N-methyl-D-aspartate Antagonist
    • 175
    Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression.
    • 40
    • PDF
    NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses
    • 1,201
    • PDF
    The role of glutamate on the action of antidepressants
    • K. Hashimoto
    • Medicine
    • Progress in Neuro-Psychopharmacology and Biological Psychiatry
    • 2011
    • 126
    A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
    • 2,379
    • PDF
    The Role of Eukaryotic Elongation Factor 2 Kinase in Rapid Antidepressant Action of Ketamine
    • 133