Is mammalian chromosomal evolution driven by regions of genome fragility?

@article{RuizHerrera2006IsMC,
  title={Is mammalian chromosomal evolution driven by regions of genome fragility?},
  author={Aurora Ruiz-Herrera and Jose Castresana and Terence J. Robinson},
  journal={Genome Biology},
  year={2006},
  volume={7},
  pages={R115 - R115}
}
A fundamental question in comparative genomics concerns the identification of mechanisms that underpin chromosomal change. In an attempt to shed light on the dynamics of mammalian genome evolution, we analyzed the distribution of syntenic blocks, evolutionary breakpoint regions, and evolutionary breakpoints taken from public databases available for seven eutherian species (mouse, rat, cattle, dog, pig, cat, and horse) and the chicken, and examined these for correspondence with human fragile… CONTINUE READING

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