Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species.

  title={Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species.},
  author={Salvatore Joseph Turco and Gerald Frank Sp{\"a}th and Stephen M Beverley},
  journal={Trends in parasitology},
  volume={17 5},
Lipophosphoglycan is a prominent member of the phosphoglycan-containing surface glycoconjugates of Leishmania. Genetic tests enable confirmation of its role in parasite virulence and permit discrimination between the roles of lipophosphoglycan and related glycoconjugates. When two different lipophosphoglycan biosynthetic genes from Leishmania major were knocked out, there was a clear loss of virulence in several steps of the infectious cycle but, with Leishmania mexicana, no effect on virulence… CONTINUE READING

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