Is it time to test biguanide metformin in the treatment of melanoma?

  title={Is it time to test biguanide metformin in the treatment of melanoma?},
  author={Michael Cerezo and Tijana Vukoji{\vc}i{\'c} Tomi{\'c} and Robert Ballotti and St{\'e}phane Rocchi},
  journal={Pigment cell & melanoma research},
  volume={28 1},
Metformin is the most widely used antidiabetic drug that belongs to the biguanide class. It is very well tolerated and has the major clinical advantage of not inducing hypoglycemia. Metformin decreases hepatic glucose production via a mechanism requiring liver kinase B1, which controls the metabolic checkpoint, AMP-activated protein kinase-mammalian target of rapamycin and neoglucogenic genes. The effects of metformin on this pathway results in reduced protein synthesis and cell proliferation… CONTINUE READING
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