Is it time to consider photobiomodulation as a drug equivalent?

@article{Karu2013IsIT,
  title={Is it time to consider photobiomodulation as a drug equivalent?},
  author={Tiina I. Karu},
  journal={Photomedicine and laser surgery},
  year={2013},
  volume={31 5},
  pages={
          189-91
        }
}
  • T. Karu
  • Published 2 May 2013
  • Biology, Medicine
  • Photomedicine and laser surgery
The question of whether photobiomodulation should be used as a drug equivalent arose in my mind after listening to presentations at the recent conference of the World Association for Laser Therapy (WALT)-2012 (Gold Cost City, Australia), and later at home when searching MEDLINE for the years 2009–2012. Photobiomodulation (earlier terms: low level laser therapy, LLLT, laser biostimulation) has been used in clinical practice for >40 years by now, and its action mechanisms on cellular and… 
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References

SHOWING 1-10 OF 37 REFERENCES
Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP.
  • T. Karu
  • Biology, Chemistry
    Photomedicine and laser surgery
  • 2010
TLDR
The role of ATP as a signaling molecule provides a new basis for explaining the versatility of low-power laser effects and broadening the understanding of universality phenomenon of LLLT.
Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review.
TLDR
A range of laser-induced inhibitory effects in diverse peripheral nerve models, which may reduce acute pain by direct inhibition of peripheral nociceptors, are identified and may result in long-term depression of pain.
Taking a light approach to treating acute ischemic stroke patients: Transcranial near-infrared laser therapy translational science
TLDR
Transcranial near-infrared laser therapy, which may promote functional and behavioral recovery via a mitochondrial mechanism and by enhancing cerebral blood flow, may eventually be established as an Food and Drug Administration (FDA)-approved treatment for stroke.
Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells
TLDR
This review suggests that an energy density value of 0.5 to 4.0 J/cm2 and a visible spectrum ranging from 600 to 700 nm of LLLT are very helpful in enhancing the proliferation rate of various cell lines.
Low-level laser irradiation alters cardiac cytokine expression following acute myocardial infarction: a potential mechanism for laser therapy.
TLDR
Although LLLI did not improve the damaged heart function, it did reduce the infarct area expansion and reveal a potential novel mechanism for applying laser therapy to the treatment of heart disease.
Collagen production in diabetic wounded fibroblasts in response to low-intensity laser irradiation at 660 nm.
TLDR
Diabetic wounded cells irradiated with 5 J/cm(2) at 660 nm showed a significant increase in cell migration, viability, proliferation, and collagen content, and LILI stimulates Col-I synthesis in diabetic wound healing in vitro at 660nm.
Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and corticosteroid-treated rats
TLDR
LLLT, by the method used, improved wound healing in the non-steroid laser-treated rats, but it was useless after corticosteroid treatment.
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
TLDR
This small feasibility study suggests that NIR-PBM may have utility for the treatment of depression and other psychiatric disorders and that double blind randomized placebo-controlled trials are indicated.
Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism.
A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis
TLDR
There is consistent evidence from small high-quality studies that red and infrared LLLT can partly prevent development of cancer therapy-induced OM.
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