Is it time for the weighted log-rank test to play a more important role in confirmatory trials?

@article{Su2018IsIT,
  title={Is it time for the weighted log-rank test to play a more important role in confirmatory trials?},
  author={Z. Su and M. Zhu},
  journal={Contemporary Clinical Trials Communications},
  year={2018},
  volume={10},
  pages={A1 - A2}
}
  • Z. Su, M. Zhu
  • Published 2018
  • Medicine
  • Contemporary Clinical Trials Communications
  • The log-rank test is frequently used to detect a potential treatment effect in randomized clinical trials with time-to-event endpoints. It is asymptotically the most powerful test under the proportional hazards setting, but it has been shown to markedly lose power when the proportional hazards assumption is violated [1]. Weighted log-rank tests with various fixed and adaptive weight functions have been proposed in the literature to increase the power of a trial when non-proportional hazards are… CONTINUE READING
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