Is it Time to Fold the Cysts Away?

  title={Is it Time to Fold the Cysts Away?},
  author={Matteus Krappitz and A Gallagher and Sorin V. Fedeles},
  journal={Trends in molecular medicine},
  volume={22 12},
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2, encoding polycystin-1 and polycystin-2, respectively. Optimizing the folding environment for polycystin-1 missense mutations may have a critical effect on the progression of ADPKD in animal models and could potentially lead to tangible therapeutic options for subgroups of ADPKD patients. 
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