Is irisin a human exercise gene?

@article{Timmons2012IsIA,
  title={Is irisin a human exercise gene?},
  author={James A. Timmons and Keith Baar and Peter K. Davidsen and Philip J. Atherton},
  journal={Nature},
  year={2012},
  volume={488},
  pages={E9-E10}
}
Arising from P. Boström et al. 481, 463–468 (2012)10.1038/nature10777Boström et al. report that exercise training induces the expression of the FNDC5 gene in human muscle, producing irisin, which can convert white fat into brown fat, so enhancing metabolic uncoupling and hence caloric expenditure, and propose that this is a new health promoting hormone. This assertion is based on experimental evidence that exogenous FNDC5 induces uncoupling protein 1 (UCP1) expression in white subcutaneous… Expand
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It is concluded from this study that resistance exercise may improve body composition possibly through increased thermogenesis in white adipose tissue through the secretion of irisin. Expand
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Modification of circulating irisin level may help in the management of a variety of endocrine and metabolic disorders. Expand
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TLDR
The data do not support the role of exercise-related signaling pathways in irisin regulation in human skeletal muscle and confirm the previous observations on increased Fndc5 expression in muscle cells from individuals with type-2-diabetes. Expand
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  • Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2013
TLDR
Assessment of the effect of an intradialytic resistance exercise training program (RETP) on plasma irisin levels of hemodialysis (HD) patients and healthy subjects found that HD patients seem to have lower Plasma irisin when compared to healthy subjects. Expand
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TLDR
The molecular mechanisms by which irisin impacts exercise, glucose homeostasis and obesity are described and its future potential as a therapeutic tool in managing obesity and metabolic syndrome is discussed. Expand
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TLDR
The acute and chronic adaptations to ET-induced irisin synthesis and secretion on the development of browning of white fat are summarized, providing an overview of the potential preventive and therapeutic role of ET on the obesity-related underlying pathways. Expand
Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?
TLDR
The data suggest that the effects of exercise on FNDC5 and irisin are not consistent, and that their role in health is questionable, and the regulatory mechanisms should be studied further. Expand
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References

SHOWING 1-10 OF 21 REFERENCES
A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
TLDR
It is shown in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin, which results in improvements in obesity and glucose homeostasis. Expand
Effect of sex differences on human MEF2 regulation during endurance exercise.
TLDR
The main finding of the present study was the implication of a joint signaling action of AMPK, HDAC5, and PGC1alpha on MEF2 in the immediate regulatory response to endurance exercise, independent of sex. Expand
The importance of brown adipose tissue.
TLDR
Brown-adipose-tissue markers have been found in obese subjects without diabetes, suggesting that anatomically dispersed brown adipocytes may promote metabolic homeostasis. Expand
Antioxidants prevent health-promoting effects of physical exercise in humans
TLDR
Consistent with the concept of mitohormesis, exercise-induced oxidative stress ameliorates insulin resistance and causes an adaptive response promoting endogenous antioxidant defense capacity and supplementation with antioxidants may preclude these health-promoting effects of exercise in humans. Expand
Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy
  • J. Timmons, O. Larsson, +8 authors C. Sundberg
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2005
TLDR
Gene expression profiling after endurance exercise training identified a range of processes responsible for the physiological remodeling of human skeletal muscle tissue, many of which were similarly regulated in DMD. Expand
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype.
TLDR
This analysis provides a comprehensive map of the transcriptomic features important for aerobic exercise-induced improvements in maximal oxygen consumption and found that both the TRT and a homologous subset of the human high responder genes were regulated to a greater degree in high respondser rodent skeletal muscle. Expand
Resistance Exercise Reverses Aging in Human Skeletal Muscle
TLDR
It is concluded that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed atThe transcriptome level, following six months of resistance exercise training. Expand
An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle.
TLDR
Findings support the hypothesis that an acute bout of low-volume HIT activates mitochondrial biogenesis through a mechanism involving increased nuclear abundance of PGC-1α. Expand
Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes
TLDR
It would appear that miRNAs can produce marked changes in target protein abundance in vivo by working in a combinatorial manner, and miRNA detection represents a new molecular biomarker strategy for insulin resistance, where micrograms of patient material is needed to monitor efficacy during drug or life-style interventions. Expand
Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes.
TLDR
It is found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups, and the adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade. Expand
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