Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?

@article{Moreira2004IsIA,
  title={Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?},
  author={Paula I. Moreira and Quan Feng Liu and Kazuhiro Honda and Mark A. Smith and Maria Sancha Santos and Catarina Resende de Oliveira},
  journal={Journal of Alzheimer's disease : JAD},
  year={2004},
  volume={6 4},
  pages={
          433-4; discussion 443-9
        }
}
Using a double mutant transgenic rat model [amyloid precursor β protein (AβPP) and presenilin 1 (PS1) mutations], that stably expresses intracellular human amyloid β (Aβ) fragments, Lopez and colleagues [1] report that intracellular Aβ accumulation in hippocampus and neocortex induces morphological alterations in the Golgi apparatus and lysosomes and an increase in lipofuscin bodies. The authors suggest that the morphological alterations in the Golgi and lysosomes elements may be due to an… Expand
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