Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?

  title={Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?},
  author={Paula I. Moreira and Quan Feng Liu and Kazuhiro Honda and Mark A. Smith and Maria Sancha Santos and Catarina Resende de Oliveira},
  journal={Journal of Alzheimer's disease : JAD},
  volume={6 4},
          433-4; discussion 443-9
Using a double mutant transgenic rat model [amyloid precursor β protein (AβPP) and presenilin 1 (PS1) mutations], that stably expresses intracellular human amyloid β (Aβ) fragments, Lopez and colleagues [1] report that intracellular Aβ accumulation in hippocampus and neocortex induces morphological alterations in the Golgi apparatus and lysosomes and an increase in lipofuscin bodies. The authors suggest that the morphological alterations in the Golgi and lysosomes elements may be due to an… Expand
Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
  • P. Reddy
  • Medicine, Biology
  • Brain Research
  • 2011
The role of tau in mitochondrial dysfunction is evaluated and how hyperphosphorylated tau impairs axonal transport of organelles in AD neurons is assessed. Expand
Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease
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Early changes in neurons of the hippocampus and neocortex in transgenic rats expressing intracellular human a-beta.
The hypothesis that intracellular Abeta accumulation not only has an impact on subcellular compartments but also potentially contributes to the neuronal cell pathology observed in AD is supported. Expand
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
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Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction
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Intracellular Accumulation of Detergent‐Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice
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Oxidative Damage Is the Earliest Event in Alzheimer Disease
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Neuronal Oxidative Stress Precedes Amyloid‐β Deposition in Down Syndrome
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Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc*
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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline.
An important role for Abeta in mediating initial pathogenic events in AD dementia is supported and treatment strategies targeting the formation, accumulation, or cytotoxic effects of Abeta should be pursued. Expand
Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β
Abstract Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number of trophic properties that emanate from the protein’s ability to bind Cu, Fe and Zn. Aβ belongs to aExpand