Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?

@article{Pyatt2008IsIE,
  title={Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?},
  author={David W. Pyatt and Ethan A. Natelson and Robert Golden},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2008},
  volume={51 1},
  pages={119-33}
}
The United States Environmental Protection Agency (EPA) recently proposed a hypothetical mode of action (MOA) to explain how inhaled formaldehyde (FA) might induce leukemia, lymphoma and a variety of other lymphohematopoietic (LHP) malignancies in occupationally exposed workers. The central hypothesis requires that B lymphocytes or hematopoietic progenitor cells (HPC) present at the "portal of entry (POE)" undergo sustained mutagenic change as a result of direct FA exposure. These modified… CONTINUE READING
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