Is hypergastrinaemia dangerous to man?

  title={Is hypergastrinaemia dangerous to man?},
  author={Werner O. C. Creutzfeldt and R. L. Lamberts},
  journal={Scandinavian journal of gastroenterology. Supplement},
Achlorhydria has been discussed as a possibly dangerous consequence of therapeutic inhibition of gastric acid secretion since the introduction of H2-receptor antagonists. The risk of long-term hypergastrinaemia has only been considered for about 5 years. The reason for this was the demonstration that gastric carcinoids (ECLomas) observed after life-long treatment of rats with the proton pump inhibitor omeprazole could also be produced in rats by other methods leading to long-lasting profound… CONTINUE READING
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