Is human blood a good surrogate for brain tissue in transcriptional studies?

@inproceedings{Cai2010IsHB,
  title={Is human blood a good surrogate for brain tissue in transcriptional studies?},
  author={Chaochao Cai and Peter Langfelder and Tova Fuller and Michael C. Oldham and Rui Luo and Leonard H van den Berg and Roel A. Ophoff and Steve Horvath},
  booktitle={BMC Genomics},
  year={2010}
}
Since human brain tissue is often unavailable for transcriptional profiling studies, blood expression data is frequently used as a substitute. The underlying hypothesis in such studies is that genes expressed in brain tissue leave a transcriptional footprint in blood. We tested this hypothesis by relating three human brain expression data sets (from cortex, cerebellum and caudate nucleus) to two large human blood expression data sets (comprised of 1463 individuals). We found mean expression… CONTINUE READING

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Weighted gene coexpression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients

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