Is hormonal treatment still an option in acne today?

  title={Is hormonal treatment still an option in acne today?},
  author={Vincenzo Bettoli and Stefania Zauli and Annarosa Virgili},
  journal={British Journal of Dermatology},
Hormonal treatment is indicated in cases of papulopustular, nodular and conglobate acne in females with identified hyperandrogenism, in adult women who have monthly flare‐ups and when standard therapeutic options are unsuccessful or inappropriate. This review summarizes the latest information on hormonal therapies including: combined oral contraceptives; anti‐androgens, such as cyproterone acetate, spironolactone and flutamide; low‐dose glucocorticoids and gonadotropin‐releasing hormone… 

Hormonal treatment of acne vulgaris: an update

  • M. Elsaie
  • Medicine
    Clinical, cosmetic and investigational dermatology
  • 2016
An update to hormonal pathogenesis of acne, the basics of endocrinal evaluation for patients with suspected hormonal acne, and an overview of the current hormonal treatment options in women are provided.

The Use of Hormonal Antiandrogen Therapy in Female Patients with Acne: A 10-Year Retrospective Study

HAAT usage is associated with shorter cumulative antibiotic durations and early HAAT initiation can decrease systemic antibiotic use in acne treatment, which is not typically used as a first-line systemic therapy in women with acne.

The effect of androgen hormones in acne pathogenesis: A review

The interruption in observing the medical help aggravates the physical and psychological injuries; thus, it is related to elucidate the disease and to find the suitable treatment for it.


Given the increasingly frequent antibiotic-resistant bacteria and the severity of the consequences if there is resistance, it is necessary to use non-antimicrobial therapy when treating patients with acne.

Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review

Evidence of limited quality to underpin the expert endorsement of spironolactone at the doses typically used (≤100 mg/day) in everyday clinical practice is identified.

Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences

Many plants seem to have inhibitory effects on the growth of bacteria, fungi and viruses in vitro in vitro for acne vulgaris, and there are a few clinical evidences about the effectiveness and safety of these plants in the treatment of acne and other skin infections.

Algorithm for acne treatment: Ibero-Latin American consensus*

The Iberian-Latin American Group of Acne Studies joined professionals with expertise and developed a practical therapeutic algorithm, adapted to the reality of Latin American countries, Spain and Portugal, with an updated review on a rational, safe and effective acne treatment.

Guidance for the pharmacological management of acne vulgaris

The author discusses the treatment of comedonal, papulopustular, and nodular/cystic/conglobate acne and proposes a simplified treatment escalation strategy that is based on disease severity and extension.

The cause and treatment of acne vulgaris: Fact versus fiction

This paper will attempt to elucidate the causes of acne which includes: hormone, diet, smoking, environment, and human biology, and common treatments that include: oral antibiotics, isotretinoin, topical treatment, hormone therapy, and light and laser therapy.



Endocrinological evaluation and hormonal therapy for women with difficult acne

  • D. Thiboutot
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2001
The use of hormonal therapy in women with severe or recalcitrant acne is focused on and various options for hormonal therapy are described, including a further discussion of oral contraceptives in the treatment of acne.

Update and Future of Hormonal Therapy in Acne

Recent research over the past several years has unraveled some of the details regarding the way that the skin and sebaceous glands synthesize and metabolize hormones, providing an impetus for future drug discovery in the hormonal treatment of acne.

Profiling and Hormonal Therapy for Acne in Women

Acne vulgaris is the most common condition treated by physicians worldwide. Though most acne patients remit spontaneously, for the ones that do not or are unresponsive to conventional therapy or have

Hormonal Therapy of Acne

  • M. Haroun
  • Medicine, Biology
    Journal of cutaneous medicine and surgery
  • 2004
Hormonal therapy is an excellent choice for female patients with acne who have SAHA syndrome, polycystic ovarian syndrome, HAIRAN syndrome, hyper androgenism, insulin resistance, acanthosis nigricans, or cutaneous hyperandrogenism and may be combined to enhance therapeutic efficacy.

Combined oral contraceptives for the treatment of acne: a practical guide.

Current issues regarding the hormonal treatment of acne in the form of combined oral contraceptives (COCs) are presented, and a practical method for implementing this therapy is proposed.

Congenital adrenal hyperplasia and acne in male patients

Three male acne patients in whom hormonal screening revealed irregularities of androgen metabolism suggestive of late‐onset congenital adrenal hyperplasia and who benefitted from low‐dose glucocorticoids are reported.

Acne: hormonal concepts and therapy.

Treatment with a gonadotropin-releasing hormone agonist in acne or idiopathic hirsutism

Six women with acne and six women with hirsutism were treated with the GnRH analog [D-Ser(But)6] LHRH-(1–9)ethylamide (Buserelin®) for 6 months (nasal spray, 1,200 μg/day) to suppress ovarian

Oral Spironolactone in Post-teenage Female Patients with Acne Vulgaris: Practical Considerations for the Clinician Based on Current Data and Clinical Experience.

This article reviews the literature focusing on the use of oral spironolactone in this subset of women with acne vulgaris, including discussions of the recommended starting dose, expected response time, adjustments in therapy, potential adverse effects, and patient monitoring.