Is high concentration of parvalbumin a requirement for superfast relaxation?

  title={Is high concentration of parvalbumin a requirement for superfast relaxation?},
  author={Boris A. Tikunov and Lawrence C Rome},
  journal={Journal of Muscle Research and Cell Motility},
It is generally thought that the rapid relaxation of fast muscles is facilitated by the Ca2+ binding protein parvalbumin (Parv). Indeed superfast swimbladder (SWB) muscle of toadfish contains the largest concentration of this protein ever observed (up to 1.5 mM). At 15°C toadfish perform a 100 Hz call, 400 ms in duration, followed by a long (5–15 s) intercall interval. It has been proposed that Parv helps sequester the Ca2+ during the call, and then Ca2+ unbinds and is pumped back into the… CONTINUE READING
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