Is herpes simplex virus associated with peptic ulcer disease?

  title={Is herpes simplex virus associated with peptic ulcer disease?},
  author={J M L{\"o}hr and Jay A. Nelson and Michael B A Oldstone},
  journal={Journal of virology},
  volume={64 5},
To test the hypothesis that herpes simplex virus type 1 (HSV-1) may be associated with peptic ulcer disease, we examined ulcerative lesions of the distal stomach and proximal duodenum for the presence of nucleic acids and antibodies specific for HSV-1. Utilizing in situ hybridization, immunocytochemistry, and polymerase chain reaction with sequencing, gastric or duodenal tissues from 4 of 22 patients (18%) with documented peptic ulcer disease demonstrated the presence of both specific HSV-1… CONTINUE READING


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