Is heparin administration necessary during induction chemotherapy for patients with acute promyelocytic leukemia?

@article{Goldberg1987IsHA,
  title={Is heparin administration necessary during induction chemotherapy for patients with acute promyelocytic leukemia?},
  author={Mark A. Goldberg and David Ginsburg and Robert J. Mayer and Richard M Stone and Maureen M. Maguire and David S. H. Rosenthal and Joseph H Antin},
  journal={Blood},
  year={1987},
  volume={69 1},
  pages={187-91}
}
The role of heparin in the treatment of the disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) remains unclear. Between 1974 and 1985, we treated 27 patients with APL using four different chemotherapeutic regimens; 23/27 (85%) had evidence of DIC either at presentation or following the initiation of induction chemotherapy. The coagulopathy was treated primarily with fresh frozen plasma and platelet transfusions; only 2/27 (7%) patients received… CONTINUE READING

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