Is hemoglobin in hemoglobin vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?

@article{Plock2005IsHI,
  title={Is hemoglobin in hemoglobin vesicles infused for isovolemic hemodilution necessary to improve oxygenation in critically ischemic hamster skin?},
  author={Jan A Plock and Claudio Contaldo and Hiromi Sakai and Eishun Tsuchida and Michael Leunig and Andrej Bani{\vc} and Michael Dieter Menger and Dominique Erni},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 6},
  pages={
          H2624-31
        }
}
The aim of this study was to test the influence of hemoglobin, encapsulated in phospholipid vesicles as an oxygen carrier, given in the course of isovolemic hemodilution to improve oxygenation in critically ischemic hamster flap tissue. Capillary hemodynamics and macromolecular leakage were investigated with intravital microscopy and analyzed off-line with the CapImage software. Partial tissue oxygen tension was measured with fluorescence quenching electrodes. The occurrence of apoptosis was… CONTINUE READING

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