Is helodermin produced by medullary thyroid carcinoma cells and normal C-cells? Immunocytochemical evidence

@article{Sundler1988IsHP,
  title={Is helodermin produced by medullary thyroid carcinoma cells and normal C-cells? Immunocytochemical evidence},
  author={F. Sundler and J. Christophe and P. Robberecht and N. Yanaihara and R. H{\aa}kanson},
  journal={Regulatory Peptides},
  year={1988},
  volume={20},
  pages={83-89}
}
Helodermin is a VIP/secretin-like 35-amino acid peptide originally isolated from the venom of the lizard Gila monster. Recently, helodermin-immunoreactive material was demonstrated in mammalian salivary glands, brain and gut. In the present study 8 human medullary thyroid carcinomas as well as 4 normal thyroid glands were examined immunocytochemically for the presence of helodermin using an antiserum raised against helodermin-(5-35) that does not cross-react with VIP or secretin. Cells… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Immunoreactive helodermin-like peptides in rat: a new class of mammalian neuropeptides related to secretin and VIP.
  • 45
Presence of helodermin‐like peptides of the VIP‐secretin family in mammalian salivary glands and saliva
  • 26
Gastrin releasing peptide in human neuroendocrine tumours
  • 29
Somatostatin immunoreactive C cells in thyroid glands from various mammalia species
  • 63
Expression of the proopiomelanocortin gene in human medullary thyroid carcinoma.
  • 28
[Immunohistochemical detection of calcitonin, ACTH, beta-MSH, beta-endorphin and somatostatin in medullary carcinoma of the thyroid. Immunoperoxidase study (PAP, ABC) of 10 cases].
  • 8
Molecular heterogeneity and biological activity of immunoreactive somatostatin in medullary carcinoma of the thyroid.
  • 22
Ectopic hormone production by endocrine tumors: Localization of hormones at the cellular level by immunocytochemistry
  • 69
Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of biological properties
  • 57
Somatostatin-immunoreactive cells in medullary carcinoma of the thyroid.
  • 79
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