Is helodermin produced by medullary thyroid carcinoma cells and normal C-cells? Immunocytochemical evidence

@article{Sundler1988IsHP,
  title={Is helodermin produced by medullary thyroid carcinoma cells and normal C-cells? Immunocytochemical evidence},
  author={F. Sundler and J. Christophe and P. Robberecht and N. Yanaihara and R. H{\aa}kanson},
  journal={Regulatory Peptides},
  year={1988},
  volume={20},
  pages={83-89}
}
Helodermin is a VIP/secretin-like 35-amino acid peptide originally isolated from the venom of the lizard Gila monster. Recently, helodermin-immunoreactive material was demonstrated in mammalian salivary glands, brain and gut. In the present study 8 human medullary thyroid carcinomas as well as 4 normal thyroid glands were examined immunocytochemically for the presence of helodermin using an antiserum raised against helodermin-(5-35) that does not cross-react with VIP or secretin. Cells… Expand
30 Citations
Chemical coding of endocrine cells of the airways: presence of helodermin-like peptides
  • 18
Effects of VIP and helodermin on thyroid hormone secretion in the mouse
  • 11
Helospectin-like immunoreactivity in the esophagus
  • 13
Helospectin-Like Peptides: Immunochemical Localization and Effects on Isolated Cerebral Arteries and on Local Cerebral Blood Flow in the Cat
  • 12
...
1
2
3
...

References

SHOWING 1-10 OF 25 REFERENCES
Immunoreactive helodermin-like peptides in rat: a new class of mammalian neuropeptides related to secretin and VIP.
  • 45
Gastrin releasing peptide in human neuroendocrine tumours
  • 29
Expression of the proopiomelanocortin gene in human medullary thyroid carcinoma.
  • 28
Somatostatin-immunoreactive cells in medullary carcinoma of the thyroid.
  • 79
...
1
2
3
...