Is glucagon a choleretic hormone at physiologic blood levels?

  title={Is glucagon a choleretic hormone at physiologic blood levels?},
  author={Carlos A. Garberoglio and K I Bickerstaff and Annette L. Baker and Abdool R. Moossa},
  journal={American journal of surgery},
  volume={143 1},
The mechanism of action and possible physiologic implications of glucagon-induced choleresis were investigated in two groups of dogs. Group I demonstrated, in chronic animal models, that glucagon-induced choleresis was not associated with increased bile acid output and was not blocked by somatostatin or Piptal, suggesting a direct stimulatory effect on bile acid-independent canalicular flow. In acute animal models (group II), glucagon infusion at rates which produced postprandial levels in the… CONTINUE READING