Is fragile X mental retardation protein involved in activity-induced plasticity of dendritic spines?

@article{Segal2003IsFX,
  title={Is fragile X mental retardation protein involved in activity-induced plasticity of dendritic spines?},
  author={Menahem Segal and Ute Kreher and Varda Greenberger and Katharina Braun},
  journal={Brain Research},
  year={2003},
  volume={972},
  pages={9-15}
}
Dendritic morphology of 2-week-old cultured neurons, taken from postnatal day 1 fragile X mental retardation gene1 knock out (FMR1-/-) mice hippocampus, were compared with cells taken from wild type mice. Under control conditions the FMR1-/- neurons displayed significantly lower spine densities compared to wild type neurons. Pharmacological stimulation of electrical activity, induced by bicuculline, caused a reduction in dendritic spine density in both the FMR1-/- and the wild type cells. In… CONTINUE READING

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