Is estradiol cardioprotection a nitric oxide-mediated effect?

  title={Is estradiol cardioprotection a nitric oxide-mediated effect?},
  author={Alan Duncan and John R Petrie and Mary Julia Brosnan and Alison M. Devlin and R A Bass and D. Stephen Charnock-Jones and John M.C. Connell and Anna F. Dominiczak and M A Lumsden},
  journal={Human reproduction},
  volume={17 7},
BACKGROUND Estradiol exerts a number of biological effects that support extensive observational data suggesting a protective role for estrogen in cardiovascular disease prevention. These include effects on lipid and carbohydrate metabolism, coagulation/fibrinolysis as well as a possible effect on vascular reactivity. It has been proposed that this might be mediated by vascular endothelial nitric oxide (NO) production. Accordingly, we designed complementary in-vivo and in-vitro studies to… CONTINUE READING