Is electroconvulsive therapy an evidence-based treatment for catatonia? A systematic review and meta-analysis

  title={Is electroconvulsive therapy an evidence-based treatment for catatonia? A systematic review and meta-analysis},
  author={Arnaud Leroy and Florian Naudet and Guillaume Vaiva and Andrew Francis and Pierre Thomas and Ali Amad},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
We aimed to review and discuss the evidence-based arguments for the efficacy of electroconvulsive therapy (ECT) in the treatment of catatonia. Randomized controlled trials (RCTs) and observational studies focusing on the response to ECT in catatonia were selected in PubMed, the Cochrane Library, Embase, and Current Controlled Trials through October 2016 and qualitatively described. Trials assessing pre-post differences using a catatonia or clinical improvement rating scale… Expand
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Electroconvulsive therapy in catatonic patients: Efficacy and predictors of response.
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Electroconvulsive therapy for schizophrenia.
  • P. Tharyan
  • Medicine
  • The Cochrane database of systematic reviews
  • 2000
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Does catatonic schizophrenia improve faster with electroconvulsive therapy than other subtypes of schizophrenia?
  • J. Thirthalli, V. Phutane, +4 authors B. Gangadhar
  • Psychology, Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2009
Catatonic schizophrenia responds faster to ECT than non-catatonic schizophrenic patients, however, the magnitude of the difference is modest. Expand
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