Is diabetes mellitus a risk factor for ovarian cancer? A case-control study in Utah and Washington (United States)

@article{Adler1996IsDM,
  title={Is diabetes mellitus a risk factor for ovarian cancer? A case-control study in Utah and Washington (United States)},
  author={Amanda Ingham Adler and Noel S Weiss and Mary L Kamb and Joseph L. Lyon},
  journal={Cancer Causes & Control},
  year={1996},
  volume={7},
  pages={475-478}
}
Insulin resistance characterizes non-insulin dependent diabetes (NIDDM). Insulin resistance may coexist in clinical syndromes with hyperestrogenism and hyperandrogenism, suggesting that the ovary may be sensitive to effects of insulin. In addition, insulin-like growth factor-I receptors, which are capable of binding insulin, have been identified in ovarian cancer tissue and are proposed to regulate cell growth. We evaluated the association between a history of diabetes mellitus and ovarian… CONTINUE READING
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