Is cytochrome P450 CYP2D activity present in pig liver?

  title={Is cytochrome P450 CYP2D activity present in pig liver?},
  author={Mette Tingleff Skaanild and Christian Friis},
  journal={Pharmacology & toxicology},
  volume={91 4},
The presence of CYP2D in pig livers has been studied using different strains of pig, different CYP2D test substrates and monoclonal and polyclonal antibodies. The results of the studies lacked consistency, therefore the aim of this study was to identify the reasons for these inconsistencies. Liver microsomes isolated from conventional pigs and minipigs were tested in Western blotting using both monoclonal and polyclonal antibodies against human CYP2D6. The microsomes were also incubated with… CONTINUE READING