Is craving mood-driven or self-propelled? Sensitization and "street" stimulant addiction.

  title={Is craving mood-driven or self-propelled? Sensitization and "street" stimulant addiction.},
  author={Frank H. Gawin and M. Elena Khalsa-Denison},
  journal={NIDA research monograph},
Pharmacological sensitization is defined as an increasing effect of a given drug dose after repeated administrations. Detected over 65 years ago during observations of animal behavior, sensitization provided an anti-thesis to the concept of pharmacological tolerance. In modern neuro-science, the sensitization concept has evolved to reflect neuroadaptive, or perhaps neurotoxic, processes and pharmacodynamics, rather than pharmacokinetic changes in plasma or brain concentrations of a drug. 


Publications referenced by this paper.

Psychosis-inducing effects of cocaine may show sensitization more than other effects

  • B. Angirst
  • Neuropsychopharmacology 10(3S:1):197S,
  • 1994
2 Excerpts

Time course of cocaine withdrawal symptoms in cocaine-abusing methadone-maintained patients

  • A. Margolin, S. K. Avants, T. R. Kosten
  • Presented at the 56th Annual Meeting of the…
  • 1994
1 Excerpt

Carbemezepine for Cocaine Dependence. Presented at the 32nd Annual Meeting of the American College of Neuropsychopharmacology

  • H. R. Kranzler, L. O. Bauer
  • Honolulu: Hawaii,
  • 1993

Standard indices as predictors of cocaine use and craving

  • J. Brown, M. E. Khalsa, F. H. Gawin
  • Problems of Drug Dependence,
  • 1992

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