Is copper chelation an effective anti-angiogenic strategy for cancer treatment?

@article{Antoniades2013IsCC,
  title={Is copper chelation an effective anti-angiogenic strategy for cancer treatment?},
  author={Vasilios Antoniades and Antonia C Sioga and E M Dietrich and Soultana Meditskou and Lambros Ekonomou and Kostantinos Antoniades},
  journal={Medical hypotheses},
  year={2013},
  volume={81 6},
  pages={1159-63}
}
Angiogenesis and the acquisition of an angiogenic phenotype is important for cancer cell proliferation. Copper in an essential trace element that participates in many enzymatic complexes like the cytochrome c, superoxide dismutase and lysyl oxidase and it is involved in processes, like embryogenesis, growth, angiogenesis and carcinogenesis. In particular, its involvement in carcinogenesis was described for the first time in oral submucous fibrosis, where fibroblasts produce large amounts of… CONTINUE READING
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