Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

@article{Magnusson1998IsCO,
  title={Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?},
  author={Kristinn P. Magnusson and Rosa Satalino and Wang Qian and George Klein and Klas G Wiman},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={2333-2337}
}
Most solid tumors are unable to grow in the ascites form, unless selected by prolonged serial transfer of peritoneal fluid (). Established ascites tumor cells grow under highly crowded, virtually anoxic conditions (). Hypoxia was recently identified as a powerful inducer of p53 dependent apoptosis (). We wished to examine whether the conversion of relatively well-vascularized solid mouse tumors into freely growing ascitic cell variants favors cell with mutated or deleted p53. We have sequenced… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-7 of 7 references

Exp

  • U Schumacher, E Adam, J Dietl, HP. Horny
  • Mol. Pathology, 64, 103 ± 113.
  • 1997

Nature, 379, 88 ± 91

  • SW Lowe, Giaccia AJ.
  • Graeber TG, Peterson JF, Tsai M, Monica K…
  • 1996

Proc

  • JH Bayle, B Elenbaas, AJ. Levine
  • Natl.
  • 1995
2 Excerpts

Mol

  • L.
  • Cell. Biol., 14, 1698 ± 1708. Kuzumaki N, Moore…
  • 1994

J

  • N Ringertz, E Klein, G. Klein
  • Natl. Cancer Inst., 18, 173 ± 190.
  • 1957

Br

  • RH Thomlinson, Gray LH.
  • J. Cancer, 9, 539 ±
  • 1955

Z

  • H. LettreÂ
  • Krebsforsch., 57, 1.
  • 1950
1 Excerpt

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