• DOI:10.3945/ajcn.111.031674
• Corpus ID: 3676310

Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study.

@article{Romaguera2012IsCW,
  title={Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study.},
  author={Dora Romaguera and Anne-Claire Vergnaud and P H M Peeters and Carla Henrica van Gils and Doris S. M. Chan and Pietro Ferrari and Isabelle Romieu and Mazda Jenab and Nadia Slimani and Francoise Clavel-Chapelon and Guy Fagherazzi and Florence Perquier and Rudolf Kaaks and Birgit Teucher and Heiner Boeing and Anne von Ruesten and Anne Tj{\o}nneland and Anja Olsen and Christina Catherine Dahm and Kim Overvad and José Ramón Quirós and Carlos Alberto Gonz{\'a}lez and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Carmen Navarro and Aurelio Barricarte and Miren Dorronsoro and Kay-Tee Khaw and Nicholas J. Wareham and Francesca L Crowe and Timothy J. Key and Antonia Trichopoulou and Pagona Lagiou and Christina Bamia and Giovanna Masala and Paolo Vineis and Rosario Tumino and Sabina Sieri and Salvatore Panico and Anne M May and Hendrik B. Bueno-De-Mesquita and Frederike L. B{\"u}chner and Elisabet Wirf{\"a}lt and Jonas Manjer and Ingegerd Johansson and Göran Hallmans and Guri Skeie and Kristin Benjaminsen Borch and Christine Louise Parr and Elio Riboli and Teresa Norat},
  journal={The American journal of clinical nutrition},
  year={2012},
  volume={96 1},
  pages={
          150-63
        }
}

• D. Romaguera, A. Vergnaud, +47 authors T. Norat
• Published 1 July 2012
• Medicine
• The American journal of clinical nutrition

BACKGROUND
In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence.

OBJECTIVE
We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

DESIGN
The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on weight management, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks, and breastfeeding for women; the score range was 0-6 for men and 0-7 for women. Higher scores indicated greater concordance with WCRF/AICR recommendations. The association between the score and cancer risk was estimated by using multivariable Cox regression models.

RESULTS
Concordance with the score was significantly associated with decreased risk of cancer. A 1-point increment in the score was associated with a risk reduction of 5% (95% CI: 3%, 7%) for total cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95% CI: 9%, 22%) for stomach cancer. Significant associations were also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, liver, and esophagus but not for prostate, ovarian, pancreatic, and bladder cancers.

CONCLUSION
Adherence to the WCRF/AICR recommendations for cancer prevention may lower the risk of developing most types of cancer.