Is complement a culprit in infection-induced forms of haemolytic uraemic syndrome?

@article{Johnson2012IsCA,
  title={Is complement a culprit in infection-induced forms of haemolytic uraemic syndrome?},
  author={Sally Ann Johnson and Aoife Waters},
  journal={Immunobiology},
  year={2012},
  volume={217 2},
  pages={235-43}
}
Haemolytic uraemic syndrome (HUS) accounts for the most common cause of childhood acute renal failure. Characterized by the classical triad of a microangiopathic haemolytic anaemia, thrombocytopaenia and acute renal failure, HUS occurs as a result of Shiga-toxin producing microbes in 90% of cases. The remaining 10% of cases represent a heterogeneous subgroup in which inherited and acquired forms of complement dysregulation have been described in up to 60%. Emerging evidence suggests that… CONTINUE READING
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