Is combining or alternating antipyretic therapy more beneficial than monotherapy for febrile children?

@article{Nabulsi2009IsCO,
  title={Is combining or alternating antipyretic therapy more beneficial than monotherapy for febrile children?},
  author={M. Nabulsi},
  journal={BMJ : British Medical Journal},
  year={2009},
  volume={339}
}
  • M. Nabulsi
  • Published 2009
  • Medicine
  • BMJ : British Medical Journal
Although fever is a beneficial host response, it is an important cause of anxiety for parents and doctors. The quest for effective treatment has led to new combination regimens of antipyretic drugs for febrile children. These are popular among caregivers and healthcare providers,1 2 3 4 but they have been tested in clinical trials only recently.4 5 6 7 8 The new regimens consist of combinations of ibuprofen and paracetamol (acetaminophen) given at variable time schedules. The main concern about… Expand
Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials.
TLDR
There is not enough evidence to say that alternating antipyretic therapy is more effective than monotherapy in the management of fever in children, but a tendency towards the reduction of mean temperatures in groups with alternating therapy is pointed to. Expand
Combined and alternating paracetamol and ibuprofen therapy for febrile children.
TLDR
There is some evidence that both alternating and combined antipyretic therapy may be more effective at reducing temperatures than monotherapy alone. Expand
Combined and alternating paracetamol and ibuprofen therapy for febrile children.
TLDR
There is some evidence that both alternating and combined antipyretic therapy may be more effective at reducing temperatures than monotherapy alone. Expand
Therapeutic procedures and use of alternating antipyretic drugs for fever management in children.
TLDR
The use of medication to control fever is a common practice, including alternating antipyretic regimens, and most caregivers consider as fever temperatures lower than those established and they reported lack of response to monotherapy and medical indication as the main reasons for alternating medication. Expand
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TLDR
The administration of medication to control fever is a common practice, including alternating antipyretics in children, and most caregivers consider fever some temperatures below those recommended, and pointed out non-response and medical advice as the main reasons for alternating antipYretics. Expand
Analysis of analgesic, antipyretic, and nonsteroidal anti-inflammatory drug use in pediatric prescriptions.
TLDR
There are significant discrepancies between clinical practice and recommended use of analgesic, antipyretic, and nonsteroidal anti-inflammatory drugs in pediatrics. Expand
Has the use of antipyretics been modified after the introduction of different concentrations of ibuprofen into the market
TLDR
The majority of children with treated febrile syndrome seen in the Emergency Room were receiving antipyretic drugs after a parental decision, and off label use of ibuprofen is increasing, and is probably due to the existence of different pharmaceutical presentations. Expand
[Has the use of antipyretics been modified after the introduction of different concentrations of ibuprofen into the market?].
TLDR
The majority of children with treated febrile syndrome seen in the Emergency Room were receiving antipyretic drugs after a parental decision, and off label use of ibuprofen is increasing, probably due to the existence of different pharmaceutical presentations. Expand
Original articleTherapeutic procedures and use of alternating antipyretic drugs for fever management in childrenCondutas terapêuticas e uso alternado de antipiréticos no manejo da febre em crianças
TLDR
The evidence on the effectiveness of alternating antipyretics in fever management is scarce and indicates clinically negligible differences, but associated factors are evaluated. Expand
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
TLDR
The result is that paracetamol does not suppress the severe inflammation of rheumatoid arthritis and acute gout but does inhibit the lesser inflammation resulting from extraction of teeth and is also active in a variety of inflammatory tests in experimental animals. Expand
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TLDR
An alternating treatment regimen of acetaminophen and ibuprofen every 4 hours for 3 days, regardless of the initial loading medication, is more effective than monotherapy in lowering fever in infants and children. Expand
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A single dose of alternating ib uprofen and acetaminophen appears to be a superior antipyretic regimen than ibuprofen mono-therapy in febrile children, and further studies are needed to confirm these findings. Expand
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TLDR
Predictive factors of this practice among pediatricians are male sex, having relatively little experience, considering ibuprofen as the drug of choice and recommending the administration of new doses of antipyretic to control mild fever despite the lack of scientific evidence to justify the practice. Expand
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TLDR
Despite the lack of scientific evidence to justify the practice, the use of alternating antipyretics is common in the treatment of febrile children and Predictive factors of this practice among pediatricians are male sex, having relatively little experience, considering ibuprofen as the drug of choice and recommending the administration of new doses of antipYretic to control mild fever. Expand
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