Is combined etanercept and methotrexate more efficacious than either monotherapy for treating RA?

Abstract

DESIGN AND INTERVENTION This was a clinical, double-blind, randomized trial of patients with RA carried out over 2 years. Patients participating in the study were treated with 25 mg etanercept twice weekly, up to 20 mg oral methotrexate weekly, or combination therapy with etanercept plus methotrexate. Radiographs of the hands, wrists, and forefeet were scored for erosions and joint-space narrowing in each year of the study. A modified intent-to-treat analysis was used, with the last observation carried forward, and in a population of completers.

DOI: 10.1038/ncprheum0299

Cite this paper

@article{Bingham2006IsCE, title={Is combined etanercept and methotrexate more efficacious than either monotherapy for treating RA?}, author={Clifton O Bingham and Joan M. Bathon}, journal={Nature Clinical Practice Rheumatology}, year={2006}, volume={2}, pages={534-535} }