Is cold paresis related to axonal depolarization?

  title={Is cold paresis related to axonal depolarization?},
  author={Hessel Franssen and Tineke A Gebbink and John H. J. Wokke and Leonard H van den Berg and Leonard J. van Schelven},
  journal={Journal of the peripheral nervous system : JPNS},
  volume={15 3},
Cold paresis may occur in multifocal motor neuropathy and lower motor neuron disease. It was proposed to reflect nerve lesions where axons are depolarized due to loss of Na/K-pump activity. In those circumstances, a further decrease in pump activity by cooling may induce extra depolarization, conduction block, and weakness. Evidence for this hypothesis is incomplete because it is unknown if cold induces depolarization in human motor axons and other factors may contribute to the symptoms. To… CONTINUE READING
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