Is clinical wheezing reliable as the endpoint for bronchial challenges in preschool children?

@article{Godfrey2004IsCW,
  title={Is clinical wheezing reliable as the endpoint for bronchial challenges in preschool children?},
  author={S. Godfrey and K. Uwyyed and C. Springer and A. Avital},
  journal={Pediatric Pulmonology},
  year={2004},
  volume={37}
}
The present study was designed to compare the clinical finding of wheeze by auscultation with an objective evaluation by acoustic means at the endpoint of a bronchial challenge in preschool children. Challenges were undertaken using a tidal breathing method in 51 preschool children as part of the investigation of possible asthma. An electronic stethoscope was used for auscultation of each lung and for the simultaneous recording of the acoustic sonogram for analysis. In 24 children, the… Expand
Timing and nature of wheezing at the endpoint of a bronchial challenge in preschool children
TLDR
Recording breath sounds continuously during tidal breathing inhalation challenges with adenosine 5′‐monophosphate adds safety to the technique by enabling the challenge to be stopped earlier, while the lack of a need to document the phase of breathing simplifies the technique. Expand
The use of bronchial challenge to diagnose asthma in preschool children.
  • S. Godfrey
  • Medicine
  • Primary care respiratory journal : journal of the General Practice Airways Group
  • 2009
TLDR
An approach to the diagnosis of asthma in preschool children by means of an inhalation bronchial challenge, where the child is exposed to increasing doses of challenge agent until wheezing is detected at a dose below that at which normal subjects respond, thus indicating bronchia hyperreactivity. Expand
A wheeze recognition algorithm for practical implementation in children
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The wheeze recognition algorithm could identify wheezes in sound files and therefore may be useful in the practical implementation of respiratory illness management at home using properly developed devices. Expand
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MCT using clinical parameters such as wheezing auscultation and SpO2 measurement could be a useful and safe test to confirm BHR among preschoolers. Expand
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A wheezing recognition algorithm from recorded respiratory sounds with a Smartphone placed near the mouth valuable in contact-free sound recording, thus valuable in the pediatric population. Expand
[Bronchial hyperresponsiveness to methacholine assessed by means of tracheal auscultation of healthy children aged under 4 years].
TLDR
As a means for assessing bronchial hyperresponsiveness, the tracheal auscultation method is appropriate, is simple to apply, and can be safely administered to unsedated children aged less than 4 years. Expand
Feasibility of Shortened Methacholine Challenge in Preschool Children
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A tripling‐dose Mch protocol is safe and practicable in children over 3 years of age, and the wheezing children were significantly more hyperresponsive than the coughing children (P < 0.05). Expand
[Bronchial hyperresponsiveness to methacholine in children under 4 years with recurrent bronchitis].
TLDR
A high percentage of children under 4 years of age affected by wheezing bronchitis had a bronchial hyperresponse, and the subsequent progression to transient, infrequent and frequent wheazing is not associated with bronchia hyperresponsiveness. Expand
Wheeze detection as a measure of bronchial challenge in young children with cough‐variant asthma and with classic asthma
TLDR
To compare the sensitivity of these two techniques as endpoints for methacholine challenge in young children with cough‐variant asthma (CVA) and with classic asthma (CA), and to investigate whether oxygen saturation levels at the presence of wheezing differ in these two groups. Expand
Utility of cough response during hypertonic histamine challenge in diagnosing asthma.
TLDR
Cough response to hyperosmolar challenge may be useful in the differential diagnosis of airway diseases and the optimal cut-off point for logCCR was 2.22, with the specificity and sensitivity to detect asthma among symptomatic subjects being 86% and 70%. Expand
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