Is chromium a trace essential metal?

@article{Stearns2000IsCA,
  title={Is chromium a trace essential metal?},
  author={Diane M. Stearns},
  journal={BioFactors},
  year={2000},
  volume={11}
}
  • D. Stearns
  • Published 2000
  • Chemistry, Medicine
  • BioFactors
If chromium is an essential metal it must have a specific role in an enzyme or cofactor, and a deficiency should produce a disease or impairment of function. To date, no chromium‐containing glucose tolerance factor has been characterized, the purpose of the low‐molecular‐weight chromium‐binding protein is questionable, and no direct interaction between chromium and insulin has been found. Furthermore, chromium3+ is treated like the toxic metals arsenic, cadmium, lead and mercury in animals… Expand
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  • Chemistry, Medicine
  • Metal ions in life sciences
  • 2013
TLDR
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  • Medicine, Chemistry
  • The Journal of nutrition
  • 2017
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  • Chemistry, Medicine
  • Proceedings of the Nutrition Society
  • 2004
TLDR
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References

SHOWING 1-10 OF 108 REFERENCES
Mechanisms of chromium carcinogenicity and toxicity.
TLDR
The chemical nature of chromium compounds and how these properties impact upon the interactions ofchromium with cellular and genetic targets, including animal and human hosts, are discussed. Expand
Mechanisms of chromium action: low-molecular-weight chromium-binding substance.
  • J. Vincent
  • Biology, Medicine
  • Journal of the American College of Nutrition
  • 1999
TLDR
A naturally-occurring oligopeptide, low-molecular-weight chromium-binding substance (LMWCr), has been found in the laboratory to activate insulin receptor kinase activity up to 7-fold with a dissociation constant of 250 picomolar in the presence of 100 nanomolar insulin. Expand
A prediction of chromium(III) accumulation in humans from chromium dietary supplements
TLDR
The use of chromium supplements for extended periods or in excess dosages should be reevaluated in terms of these established models, which predict that chromium(III) can accumulate in human tissues to reach the levels at which DNA damage has been observed in animals and in vitro. Expand
Essentiality of chromium in humans.
  • R. Anderson
  • Medicine
  • The Science of the total environment
  • 1989
TLDR
Well controlled studies involving human subjects have demonstrated beneficial effects of supplemental chromium on fasting glucose, glucose tolerance, blood lipids, insulin binding, and hypoglycemic blood glucose values and symptoms. Expand
Chromium in human nutrition: a review.
  • W. Mertz
  • Medicine
  • The Journal of nutrition
  • 1993
TLDR
This review summarizes the results of 15 controlled studies supplementing defined Cr(III) compounds to subjects with impaired glucose tolerance with the conclusion that chromium deficiency is a factor in the much discussed "Syndrome X" of insulin resistance. Expand
Chromium metabolism and its role in disease processes in man.
  • R. Anderson
  • Medicine
  • Clinical physiology and biochemistry
  • 1986
TLDR
Dietary intake of Cr is suboptimal and this is exacerbated by increased Cr losses due to stress and certain refined foods including simple sugars that enhance Cr losses. Expand
Dietary chromium effects on tissue chromium concentrations and chromium absorption in rats
Chromium (Cr) absorption is low (<1%) and there is a need to find Cr compounds that are absorbed better than inorganic Cr salts. Therefore, the incorporation of nine different chromium (Cr) compoundsExpand
Chromium research from a distance: from 1959 to 1980.
  • W. Mertz
  • Chemistry, Medicine
  • Journal of the American College of Nutrition
  • 1998
TLDR
Of several approaches for solving this problem, the most feasible might be to standardize the urinary chromium response following an insulinogenic challenge, such as an oral load of glucose or of glucose plus fructose with urine collection before and during the 2-hour test. Expand
Effect of trivalent chromium complexes on glucose uptake by epididymal fat tissue of rats.
TLDR
In order to define the site of action of GTF more closely, glucose uptake was measured with epididymal fat tissue from rats on GTFdeficient and GTF-supplemented diets, and a study was made of the effect in vitro of trivalent chromium complexes on the incorporation of glucose into fat. Expand
Purification and chromium-excretory function of low-molecular-weight, chromium-binding substances from dog liver.
TLDR
Results indicate that LMCr plays an important role in the detoxification and excretion of chromium in mammals and remarkably reduced the mortality rates of mice acutely poisoned with chromium chloride. Expand
...
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3
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