Is cefazolin inferior to nafcillin for treatment of methicillin-susceptible Staphylococcus aureus bacteremia?

@article{Lee2011IsCI,
  title={Is cefazolin inferior to nafcillin for treatment of methicillin-susceptible Staphylococcus aureus bacteremia?},
  author={Shinwon Lee and Pyoeng Gyun Choe and Kyoung-Ho Song and Sang-Won Park and Hong Bin Kim and Nam Joong Kim and E I Kim and Wan Beom Park and Myoung-don Oh},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 11},
  pages={5122-6}
}
About 20% of methicillin-susceptible Staphylococcus aureus (MSSA) isolates have a substantial inoculum effect with cefazolin, suggesting that cefazolin treatment may be associated with clinical failure for serious MSSA infections. There are no well-matched controlled studies comparing cefazolin with nafcillin for the treatment of MSSA bacteremia. A retrospective propensity-score-matched case-control study was performed from 2004 to 2009 in a tertiary care hospital where nafcillin was… CONTINUE READING