Is cannabis neurotoxic for the healthy brain? A meta‐analytical review of structural brain alterations in non‐psychotic users

  title={Is cannabis neurotoxic for the healthy brain? A meta‐analytical review of structural brain alterations in non‐psychotic users},
  author={Matteo Rocchetti and Alessandra Crescini and Stefan J. Borgwardt and Edgardo Caverzasi and Pierluigi Politi and Zerrin Atakan and Paolo Fusar-Poli},
  journal={Psychiatry and Clinical Neurosciences},
Despite growing research in the field of cannabis imaging, mostly in those with a psychotic illness, the possible neurotoxic effects of smoked cannabis on the healthy brain have yet to be fully understood. There appears to be a need to evaluate the existing imaging data on the neuroanatomical effects of cannabis use on non‐psychotic populations. 
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Vulnerability to psychosis is associated with consistent GM decreases in prefrontal and temporolimbic areas and neuroanatomical alterations in temporal regions may underlie the clinical onset of psychotic symptoms.
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These findings indicate that heavy daily cannabis use across protracted periods exerts harmful effects on brain tissue and mental health.
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The nature of the relationship between cannabis use and anxiety, as well as the possible clinical, diagnostic and causal implications, are reviewed.
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Investigating the effects of cannabis smoking on the morphology of the hippocampus in older, long-term cannabis users found no significant adjusted differences in volumes of gray matter, white matter, cerebrospinal fluid, or left and right hippocampus.
Neuroimaging in cannabis use: a systematic review of the literature
Functional neuroimaging studies suggest a modulation of global and prefrontal metabolism both during the resting state and after the administration of THC/marijuana cigarettes.
Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing.
CONTEXT The aberrant processing of salience is thought to be a fundamental factor underlying psychosis. Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of
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The effects of frequent cannabis use during adolescence could be different from and more serious than during adulthood, an issue increasingly recognized in the field of cannabis research.