Is cancer stem cell a cell, or a multicellular unit capable of inducing angiogenesis?

@article{Rak2006IsCS,
  title={Is cancer stem cell a cell, or a multicellular unit capable of inducing angiogenesis?},
  author={Janusz W. Rak},
  journal={Medical hypotheses},
  year={2006},
  volume={66 3},
  pages={
          601-4
        }
}
Cancer stem cells are presently viewed as carriers of the growth initiating potential, repopulation capability and drug resistance in tumors. However, many of these fundamental properties of cancer are host-related, modified by cell-cell interactions and/or dependent on angiogenesis. Indeed, it is well established that co-injection of cancer cells with their irradiated (mitotically dead) counterparts, or with Matrigel can significantly increase their tumor forming capacity (i.e. the attribute… CONTINUE READING

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  • Janusz Rak
  • Medicine, Biology
  • Seminars in thrombosis and hemostasis
  • 2010