Is cancer a disease of self-seeding?

  title={Is cancer a disease of self-seeding?},
  author={Larry Norton and Joan Massagu{\'e}},
  journal={Nature Medicine},
Although epithelial cancers are diverse genotypically and phenotypically, several features are universal1–5.One of these is the abnormal capacity of cancer cells to migrate, which manifests in two ways. The first is invasion: the cells’ ability to become dislodged and travel within the tissue of origin. The second, metastasis, involves travel beyond the tissue of origin. Aberrant cell mobility is thought to be distinct from (while sharing some molecular pathways with) another universal feature… CONTINUE READING

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NATURE MEDICINE © 20 06 N at ur e P ub lis hi ng G ro up ht tp :// w w w .n at ur e

Miller, K.D
J. Clin. Oncol • 2005


C. Dang, T. A. Gilewski, A. Surbone, L. Norton
Cancer Medicine • 2003

Cytokinetics. in Cancer Medicine 6th edn

C. Dang, T. A. Gilewski, A. Surbone, L. Norton

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