Is brain uptake of leptin in vivo saturable and reduced by fasting?

@article{Karonen1998IsBU,
  title={Is brain uptake of leptin in vivo saturable and reduced by fasting?},
  author={Sirkka-Liisa Karonen and Heikki A Koistinen and P{\"a}ivi Nikkinen and Veikko A. Koivisto},
  journal={European Journal of Nuclear Medicine},
  year={1998},
  volume={25},
  pages={607-612}
}
Leptin is a peptide hormone produced by adipocytes which provides a negative feedback signal to control the amount of body fat. The action of leptin on food intake and weight loss is thought to be mediated by interaction with its hypothalamic receptor. We examined the biodistribution and brain uptake of radioiodinated leptin (123I-leptin) by dynamic gamma imaging in six anaesthetized New Zealand white rabbits. Leptin uptake was seen in the brain, lungs, liver and kidneys. In the brain, increase… CONTINUE READING
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