Is body composition an important variable in the pharmacokinetics of anticancer drugs?

Abstract

Variability between individual patients in the therapeutic and toxic effects of anticancer drugs is one of the major problems confronting clinical oncology. Because of the narrowness of the therapeutic window that separates concentrations that are active from those causing unacceptable toxicity, any means to allow optimisation of drug exposure is worthy of… (More)
DOI: 10.1007/BF00686105

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