Is biological aging accelerated in drug addiction?

@article{Bachi2017IsBA,
  title={Is biological aging accelerated in drug addiction?},
  author={Keren Bachi and Salvador Sierra and Nora D. Volkow and Rita Z. Goldstein and Nelly Alia-Klein},
  journal={Current Opinion in Behavioral Sciences},
  year={2017},
  volume={13},
  pages={34-39}
}

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References

SHOWING 1-10 OF 69 REFERENCES
Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers
  • A. Reece
  • Medicine, Biology
    Immunity & Ageing
  • 2007
TLDR
It is demonstrated for the first time that addiction is associated with an altered profile of common biomarkers of ageing raising the possibility that the ageing process may be altered in this group.
Oxidative Stress and Drugs of Abuse: An Update
TLDR
This review describes the evidences for oxidative damage and depletion of antioxidants upon exposure to drugs of abuse, especially amphetamines, cocaine and opiates, and discusses the sources of oxidative stress induced by drugs ofabuse.
Neurobiologic Advances from the Brain Disease Model of Addiction.
TLDR
It is concluded that neuroscience continues to support the brain disease model of addiction, which has led to the development of more effective methods of prevention and treatment and to more informed public health policies.
Morphine as a Potential Oxidative Stress-Causing Agent
TLDR
It appears that different tissues may respond to morphine diversely and are distinctly susceptible to oxidative stress and subsequent oxidative damage of biomolecules.
Neuroprotective strategies in drug abuse‐evoked encephalopathy
TLDR
The major pathways for the organ and CNS toxicity could be related to ischemic events as well as increased cell damage due to metabolic or mitochondrial dysfunction resulting in increased excitotoxicity, reduced energy production, and lowered antioxidant potential.
Positive oxidative stress in aging and aging-related disease tolerance☆
Mitochondria: The Next (Neurode)Generation
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging
Cocaine dependence: a fast-track for brain ageing?
Cocaine-dependent individuals anecdotally appear aged and their mortality rates are estimated up to eight times higher than in the healthy population.1 Psychological and physiological changes
Drug addiction is associated with leukocyte telomere length
TLDR
It is shown that drug abusers exhibited significantly shorter LTLs than controls, and the time before relapse also presented an inverse correlation with LTL, which may offer a partial explanation for the effects of drug addiction on health.
...
...