Is autoimmunity a matter of sex?

  title={Is autoimmunity a matter of sex?},
  author={Ana Lleo and Pier Maria Battezzati and Carlo Selmi and M Eric Gershwin and Mauro Podda},
  journal={Autoimmunity reviews},
  volume={7 8},
Autoimmune diseases include several conditions that cumulatively are estimated to affect over 5% of the US population with a striking female predominance reported for most of them. The cause and mechanisms of this sex bias remains unknown despite multiple proposed hypotheses. Indeed, it is well established in several experimental settings that the human immune system exhibits sexual dimorphism with basic immune responses differing between females and males. Among candidate factors to explain… CONTINUE READING


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