Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?

@article{z2009IsAD,
  title={Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?},
  author={Oğuzhan {\"O}z and Zeki G{\"o}kçil and Semai Bek and Erdinç Çakır and Zeki Odabaşı},
  journal={Epilepsy Research},
  year={2009},
  volume={87},
  pages={54-58}
}

Asymmetric dimethylarginine may contribute to vascular risk factors in patients receiving antiepileptic drug treatment

This study investigated the effect of VPA and CBZ monotherapy on plasma levels of ADMA and homocysteine and serum levels of folate and vitamin B12 in patients with newly diagnosed epilepsy and concluded that elevated ADMA levels may be responsible for the increased cardiovascular risk in Patients with epilepsy who are receiving AED therapy.

Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs

Long-term use of antiepileptic drugs, especially old-generation polytherapy, can increase lipid profiles, homocysteine levels, ADMA, and carotid intima-media thickness compared to the minimal effect of new AEDs.

Do Antiepileptic Drugs Change the Levels of Arginine Derivatives in Epileptic Children Treated with Polytherapy? The Results of a Case–Control Study

The aim of the present study was to analyze the levels of arginine derivatives in children with epilepsy who were treated with multiple AEDs to answer the question whether pediatric patients may be at increased risk of CVD in the future.

Concentrations of the Selected Biomarkers of Endothelial Dysfunction in Response to Antiepileptic Drugs: A Literature Review

Because of the role of these parameters in the pathogenesis of CVD, knowledge of HCys, ADMA, and hArg concentrations in patients with epilepsia treated with AED appears to be of significant importance.

A possible role of cyclooxygenase‐2 in the relationship between sleep and sudden unexpected death in epilepsy

This study investigated the effect of VPA and CBZ monotherapy on plasma levels of ADMA and homocysteine and serum levels of folate and vitamin B12 in patients with newly diagnosed epilepsy and concluded that elevated ADMA levels may be responsible for the increased cardiovascular risk in Patients with epilepsy who are receiving AED therapy.

Asymmetric Dimethylarginine as a Vascular Risk Factor in Antiepileptic Drug Treated Individuals

Elevated asymmetric Dimethylarginine levels may be responsible for the increased cardiovascular risk in patients with epilepsy who are receiving antiepileptic drug therapy, and the role of asymmetric dimethylarg inine should be considered in children treated with antiePileptic drugs.

Effect of Certain Pharmacotherapies on Plasma Asymmetric Dimethyl Arginine ( ADMA

  • Patil
  • Biology, Medicine
  • 2016
Drugs like proton pump inhibitors; antiepileptics like carbamazepine and sodium valproate and also COX 2 inhibitors are observed to raise ADMA levels, hence their choice should be done carefully and cautiously.

References

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Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease.

It is confirmed that ADMA is accumulated in ESRD, and hemodialysis and peritoneal dialysis patients exhibit significantly lower ADMA levels than do HD-treated patients.

Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction.

Elevations of ADMA associated with impaired endothelium-dependent relaxation were found in chronic hyperhomocyst(e)inemia, as well as after acute elevation of plasma homocyst (e)ine following oral methionine intake.

Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.

It is demonstrated that hyperhomocysteinemia causes tissue-specific decreases in DDAH expression without altering plasma ADMA levels in mice with endothelial dysfunction.

Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease

Pyridoxine plus folic acid treatment normalizes homocysteine metabolism in virtually all patients, and appears to ameliorate endothelial dysfunction.