Is ascites caused by impaired hepatic inactivation of blood borne endogenous opioid peptides?

@article{Thornton1988IsAC,
  title={Is ascites caused by impaired hepatic inactivation of blood borne endogenous opioid peptides?},
  author={John Richard Thornton and Hongbin Lu A. Gordon Emslie Dean and M. S. Losowsky},
  journal={Gut},
  year={1988},
  volume={29 9},
  pages={1167-72}
}
Methionine enkephalin and catecholamines were measured in carefully collected plasma samples from 25 patients with cirrhosis and ascites, and 25 with cirrhosis without ascites, 15 disease and 15 healthy controls. Methionine enkephalin was invariably raised in the ascites group, the median value being 4.6-6.9 times that of the other three groups. Similarly, in the ascites group, median noradrenaline was increased 2.5-4.2 and median adrenaline 1.8-2.5 times that of the other groups. Plasma… CONTINUE READING

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A role for the kidneys and liver in plasma beta - endorphin elimination ?

  • Thornton, MS Losowksy
  • Clin Sci
  • 1988

Is plasma methionine enkephalin a mediator of some of the clinical manifestations of acute liver failure ?

  • Thornton, MS Losowsky
  • J Hepatol
  • 1987

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